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Women’s health and midwifery
Population data suggest persistently high risk of pregnancy complications in women with chronic kidney disease
  1. Ju-Lee Oei1,2,
  2. Yoga Kandasamy3
  1. 1 Department of Newborn Care, Royal Hospital for Women, Randwick, New South Wales, Australia
  2. 2 School of Women’s and Children’s Health, University of New South Wales, Randwick, New South Wales, Australia
  3. 3 Department of Neonatology, Townsville Hospital and Health Service, Townsville, Queensland, Australia
  1. Correspondence to Professor Ju-Lee Oei, Department of Newborn Care, Royal Hospital for Women, Randwick, NSW 2031, Australia; j.oei{at}

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Commentary on: Al Khalaf SY, O'Reilly ÉJ, McCarthy FP, et al. Pregnancy outcomes in women with chronic kidney disease and chronic hypertension: a National cohort study. Am J Obstet Gynecol 2021:S0002-9378(21)00225-8. doi: 10.1016/j.ajog.2021.03.045.

Implications for practice and research

  1. Pregnant women with chronic kidney disease are at risk of pre-eclampsia, preterm birth and caesarean delivery.

  2. They need close surveillance with multidisciplinary expertise to reduce the risk of pregnancy complications which in turn may increase risk of postpartum adverse outcomes if untreated.


Chronic kidney disease (CKD) affects up to 3% of pregnant women in developed countries and is associated with adverse pregnancy outcomes. However, due to the heterogeneity of CKD and evolving and advances in therapy, it is uncertain if poor outcomes are associated with any specific maternal characteristics. Understanding these differences will allow improved identification, intervention and prognostication for women with CKD.


Al Khalaf et al 1 used population data linkage methods to address these knowledge gaps. …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.