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- reproductive medicine
- bleeding disorders & coagulopathies
- fetal medicine
- maternal medicine
- prenatal diagnosis
Commentary on: Hastie R, Tong S, Wikström AK, et al. Aspirin use during pregnancy and the risk of bleeding complications: a Swedish population-based cohort study. Am J Obstet Gynecol. 2020 Jul 17:S0002-9378(20)30737-7. doi:10.1016/j.ajog.2020.07.023.
Implications for practice and research
Using aspirin for prevention of pre-eclampsia is associated with increased risk of postpartum haemorrhage, postpartum hematoma and possibly neonatal intracranial haemorrhage.
More liberal or universal administration of aspirin may have more risk than benefits due to bleeding risk, but still strongly advised in high-risk pre-eclampsia pregnant women.
Future prospective studies are needed to determine bleeding risks with widespread use of aspirin in pregnancy.
Aspirin is widely offered to pregnant women at risk of developing pre-eclampsia, secondary to its anti-inflammatory and antiplatelet properties.1 There has been a trend towards increasing the use of aspirin universally to pregnant women, secondary to perceived safety of aspirin.2 Recent large randomised control trials report …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.