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Commentary on: Coffey MJ, Garg M, Homaira N, et al. Probiotics for people with cystic fibrosis. Cochrane Database Syst Rev 2020;1:CD012949. doi:10.1002/14651858.CD012949.pub2.
Implications for practice and research
Probiotics may be considered for children and adults with cystic fibrosis (CF) and might have some limited health benefits.
Further research is required on the effects of varying duration, dose and type of probiotics on children and adults with CF.
Cystic fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene1 and affects an estimated 70 000 adults and children around the world.2 The CFTR impairment causes gut ecosystem imbalance.3 It has been suggested that probiotics can help with restoring gut microbiota in patients with CF.4 This review aimed to summarise the current evidence on the efficacy and safety of probiotics for improving health outcomes …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.