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Health promotion and public health
Modelling suggests that high human papilloma virus (HPV) vaccination coverage in combination with high uptake screening can lead to cervical cancer elimination in most low-income and lower-middle-income countries (LMICs) by the end of the century
  1. Saivash Moradi
  1. Assistant Professor of Community Medicine, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  1. Correspondence to Professor Saivash Moradi, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences Faculty of Medicine, Sari, Iran; d.smor86{at}

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Commentary on: Brisson M, Kim JJ, Canfell K, et al. Impact of HPV vaccination and cervical screening on cervical cancer elimination: a comparative modelling analysis in 78 low-income and lower-middle-income countries. Lancet 2020:22;395 (10224):575–90. doi: 10.1016/S0140-6736(20)30068-4.

Implications for practice and research

  • The results of this comparative modelling analysis could help the WHO to order and implement intervention strategies to accelerate cervical cancer eradication in lower-middle-income countries (LMICs).

  • In order to achieve a more accurate projection in each LMICs, it is necessary to pay serious attention to conducting researches using population-based cancer registries and surveillance data.


The point prevalence of human papilloma virus (HPV) infection worldwide is estimated at approximately 10%.1 It is said that all sexually active people will become infected with at least one type of anogenital HPV during their lifetime.1 It has been a quarter of a century since the role of HPV …

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.