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Commentary on: Early Breast Cancer Trialists’ Collaborative Group. Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials. Lancet 2019;393:1440–52. doi:10.1016/S0140-6736(18)33137-4. Epub 8 February 2019.
Implications for practice and research
Oncology nurses are in the key role to put in practice a proactive approach to determine successful completion of dose-intense regimens.
This meta-analysis provides support for nursing research on the effect of nursing interventions delivered to women receiving a dose-intense regimen (eg, symptoms and quality of life).
Researchers have demonstrated that anthracycline and taxane regimen reduce mortality by a third compared with no chemotherapy in early breast cancer, independently of tumour characteristics.1 A previous report suggested that dose-intensification strategies including chemotherapy administration every 2 weeks or giving higher dose of drugs sequentially rather than lower dose concurrently …
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Commissioned; internally peer reviewed.