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Child health
Moderate-to-vigorous exercise is beneficial and can improve symptoms of fatigue and depression in young people with paediatric-onset multiple sclerosis and other demyelinating conditions
  1. Karen McGuigan1,
  2. Charles J McGuigan2
  1. 1 School of Nursing and Midwifery, Queen’s University Belfast, Belfast, UK
  2. 2 Data and Analysis, NorthWest Research, NI, Londonderry, UK
  1. Correspondence to Dr Karen McGuigan, School of Nursing and Midwifery, Queen’s University Belfast, Belfast BT9 7BL, UK; k.mcguigan{at}

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Commentary on: Stephens S, Shams S, Lee J, et al. Benefits of physical activity for depression and fatigue in multiple sclerosis: a longitudinal analysis. J Pediatr 2019;209:226–32.

Implications for practice and research

  • Young people with paediatric-onset multiple sclerosis (POMS) experience increased depression and fatigue across illness duration; healthcare professionals should be cognisant of the need to address these symptoms to ensure improved well-being and trajectory of these psychosocial aspects over time.

  • Additional longitudinal research among young people with MS is required to address symptomology and improve well-being among this grouping; and also to inform trends, potential interventions and treatment for the adult population.


Paediatric-onset multiple sclerosis presents in childhood or adolescence with fatigue and depression common among those living with POMS.1 Fatigue and depression are often comorbid conditions that have been consistently …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.