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Commentary on: Sheppard et al. Benefits and harms of antihypertensive treatment in low-risk patients with mild hypertension. JAMA Internal Medicine
Implications for practice and research
A risk-based approach that includes tailored targets and comorbidity may be optimal in the management of hypertension.1
Research to examine risk-over-time as a prognostic indicator in the development of cardiovascular disease (CVD) in low-risk patients may provide greater insight into the benefit of treating mild hypertension in these individuals.1
Hypertension, a growing global burden, affects one-quarter of the world’s population.1–3 Uncontrolled hypertension can lead to life-threatening sequelae, decreased quality of life and increased expenditures by health systems.1–3 Evidence-based guidelines, a mainstay of modern practice, feature prominently in clinical decision-making.3 4 Yet, some guidelines can spur controversy.
Sheppard et al conducted a harm-benefit analysis of …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.