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There is an urgent need for evidence-based internationally agreed guidelines for the assessment of neonates at risk of developing early-onset sepsis
  1. Siba Prosad Paul,
  2. Kerrie Richardson
  1. Department of Paediatrics, Torbay Hospital, Torquay, UK
  1. Correspondence to Dr Siba Prosad Paul, Department of Paediatrics, Torbay Hospital, Torquay TQ2 7AA, UK; siba.paul{at}

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Commentary on: Mukhopadhyay S, Taylor JA, Von Kohorn I, et al. Variation in sepsis evaluation across a national network of nurseries. Pediatr 2017;139:e20162845.

Implications for practice and research

  • An optimal approach for early-onset sepsis (EOS) risk assessment in neonates would allow for standardised quality of care and would minimise disparities in management.

  • There is a need for the evaluation of current practices and outcomes in managing neonates at risk for EOS, as well as the development of internationally agreed evidence-based guidelines.


Neonatal sepsis is a leading cause of morbidity and mortality. However, there are substantial differences in the practice of risk assessment of neonates with suspected EOS. Attempts have been made to streamline the management pathways in the USA, UK and elsewhere through publication of the national guidelines.1 2 A rational approach is needed to …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.