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Case—controlled study
Caesarean section increases risk of preterm birth in subsequent pregnancy
  1. Laura Visser1,
  2. Marjon A de Boer1,
  3. Ben W Mol2,3
  1. 1VU Medical Center, Amsterdam, The Netherlands
  2. 2The Robinson Research Institute, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia
  3. 3The South Australian Health and Medical Research Institute Adelaide, Adelaide, South Australia, Australia
  1. Correspondence to: Laura Visser, Department of Obstetrics and Gynecology, VU University Medical Center, De Boelelaan 1118, Amsterdam 1081 HZ, The Netherlands; l.visser1{at}

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Commentary on: OpenUrl

Implications for practice and research

  • Caesarean section was identified as a risk factor for preterm birth in a subsequent pregnancy, however it is not known if the relationship between caesarean section and preterm birth is causal.

  • Large observational studies might provide additional information regarding the relationship between caesarean section and the increased risk on preterm birth.


The aetiology of spontaneous preterm birth remains, despite many publications on the subject, largely indefinite.1 Studies focus on identification of risk factors for preterm birth in order to develop tailor-made care. Risk factor identification might however also provide clues in unravelling the pathophysiological processes leading …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.