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Implications for practice and research
Prostate-selective α-antagonists are associated with a small increased risk of falls and fall-related fractures.
Healthcare practitioners should consider counselling patients on the increased risk for falls prior to starting prostate-selective α-antagonists.
Future studies should evaluate strategies to reduce the risk of falls in men prescribed α-antagonists.
Lower urinary tract symptoms (LUTS) due to prostate enlargement are almost ubiquitous among older men. α-Antagonists relax the smooth muscle of the prostate to help improve voiding. However, as α-antagonists are associated with the side effects of hypotension and dizziness due to their action on peripheral …
Funding University of Malaya Grand Challenge Fund (grant number GC002B-14HTM).
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.