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Review: minor analgesics are effective for primary dysmenorrhoea

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Question What is the efficacy and safety of naproxen, ibuprofen, mefenamic acid, and aspirin for primary dysmenorrhoea (painful periods)?

Data sources

Studies from 1966 to March 1997 were identified by searching Medline, Embase/Excerpta Medica, and Science Citation Index using search terms including dysmenorrhoea, naproxen, ibuprofen, mefenamic acid, aspirin (acetylsalicyclic acid), and paracetamol (acetaminophen); reviewing bibliographies of relevant articles; and communicating with manufacturers.

Study selection

Published English language studies were selected if they were randomised controlled trials of naproxen, ibuprofen, mefenamic acid, aspirin, or paracetamol for dysmenorrhoea treatment.

Data extraction

Data …

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  • Sources of funding: no external funding.

  • For correspondence: Prof A Li Wan Po, Centre for Evidence-Based Pharmacotherapy, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK. Fax +44 (0)121 359 4693.