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HRT did not reduce coronary events in postmenopausal women with existing heart disease

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Question Can oestrogen plus progestin prevent recurrent non-fatal myocardial infarction (MI) and coronary heart disease (CHD) mortality in postmenopausal women with established CHD?


Randomised, double blind, placebo controlled trial with mean follow up of 4.1 years (Heart and Estrogen/progestin Replacement Study [HERS]).


20 outpatient and community settings in the US.


2763 postmenopausal women between 44 and 79 years of age (mean age 67 y, 89% white) with established CHD who had not had a hysterectomy. Exclusion criteria were CHD event ≤6 months before study; sex hormone use ≤3 months before study; history of breast cancer, deep vein thrombosis, pulmonary embolism, hyperplasia, or endometrial cancer; abnormal mammogram or Papanicolaou test; increased serum triglyceride or serum aspartate aminotransferase concentrations; geographic inaccessibility; …

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  • Source of funding: Wyeth-Ayerst Research.

  • For correspondence: Dr S Hulley, University of California, San Francisco, Box 0886, San Francisco, CA 94143, USA. Fax +1 415 476 6014.

  • A modified version of this abstract appears in ACP Journal Club.