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A Mediterranean type diet reduced all cause and cardiac mortality after a first myocardial infarction

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Question In patients who have had a first myocardial infarction (MI), does a Mediterranean type diet (rich in α linolenic acid) reduce death, subsequent MI, and cancer better than a diet similar to the Step 1 American Heart Association (AHA) diet?


Randomised controlled trial with a mean follow up of approximately 4 years (Lyon Diet Heart Study).


A coronary care unit in Lyon, France.


605 patients {mean age 54 y, 91% men}* who had a first MI. {Exclusion criteria were severe heart failure, hypertension [blood pressure >180/110 mm Hg], inability to complete an exercise test, or other conditions thought to limit survival or participation}*.


302 patients were allocated to a Mediterranean type diet consisting of increased bread, cereals, fresh fruit and vegetables, legumes, and fish; moderate amounts of red wine …

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  • Source of funding: not stated.

  • For correspondence: Dr M de Lorgeril, Explorations Fonctionnelles Cardio-Respiratoires, CHU Nord de Saint-Etienne, Niveau 6, 42055 Saint-Etienne Cedex 2, France. Fax +33 4 77 82 84 61.

  • A modified version of this abstract appears in ACP Journal Club.

  • * de Lorgeril M, Renaud S, Mamelle N, et al. Lancet 1994:343:1454–9.