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Implications for practice and research
Subclavian site should be preferred for central venous access (CVA) with a low risk of pneumothorax.
Excluding patients before randomisation represents a selection bias. Post hoc sensitivity analysis may reduce the bias without fully balancing it. An adjudication committee, unaware of study-group assignments, may compensate for the absence of feasible blindness.
Infection, thrombosis and mechanical adverse events are complications of central venous catheterisation. Catheter-related bloodstream infection (CRBI) has a significant impact on morbidity, mortality and health costs.1 Randomised controlled trials (RCT) found that subclavian access was associated with a lower …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.