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Cohort study
Oral fluconazole is often used during pregnancy in the treatment of vulvovaginal candidiasis despite safety concerns to the fetus
  1. Julianna Briglio
  1. Obstetrics and Gynaecology Department at the Group Health Centre, Sault Ste. Marie, Ontario, Canada
  1. Correspondence to : Julianna Briglio, Obstetrics and Gynecology Department at the Group Health Centre, Sault Ste. Marie, Ontario, Canada; briglio_j{at}

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Commentary on: OpenUrlCrossRefPubMed

Implications for practice and research

  • Prescription of oral fluconazole requires caution when prescribing to the pregnant population, especially in the first 22 weeks of gestation.

  • Specific dose-related risks need further research.

  • Future research should examine why practitioners are prescribing fluconazole to the pregnant population when the current treatment of topical azoles is effective and safe.


According to the authors of this study, 1 in 10 pregnant women will have acquired vulvovaginal candidiasis (VVC), and 75% of women are affected by this infection at least once in their lifetime.1 Pregnancy predisposes women to VVC, and topical azoles are …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.