You are here

  • Home
  • Archive
  • Volume 19, Issue 1
  • In people with atrial fibrillation receiving antithrombotics, short-term non-steroidal anti-inflammatory drug exposure increases risk of serious bleeding

Article Text

Article menu
Download PDFPDF
Adult nursing
Cohort study
In people with atrial fibrillation receiving antithrombotics, short-term non-steroidal anti-inflammatory drug exposure increases risk of serious bleeding
  1. Aung Myat
  1. The Rayne Institute, Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, London, UK
  1. Correspondence to : Dr Aung Myat, Cardiovascular Division, The Rayne Institute, 4th Floor Lambeth Wing, St Thomas’ Hospital, London SE1 7EH, UK; aung.myat{at}kcl.ac.uk
View Full Text

http://dx.doi.org/10.1136/eb-2014-102047

Statistics from Altmetric.com

    Commentary on: Lamberts M, Lip GYH, Hansen ML, et al. Relation of non-steroidal anti-inflammatory drugs to serious bleeding and thromboembolism risk in patients with atrial fibrillation receiving antithrombotic therapy Ann Intern Med 2014;161:690–8.OpenUrlCrossRefPubMedWeb of Science

    Implications for practice and research

    • Short courses of non-steroidal anti-inflammatory drugs (NSAIDs) should be used with caution in patients with atrial fibrillation (AF) already taking antithrombotic therapy for stroke prevention since there is an increased risk of serious bleeding and clot formation.

    • Research needs to be carried out on whether combined NSAID and non-vitamin K oral anticoagulant use is also associated with serious bleeding and thromboembolism.

    Context

    Since the discovery of salicylic acid from willow bark in the mid-19th century, a multitude of NSAIDs have been developed. They are widely used for their anti-inflammatory and analgesic properties, good tolerability and speed of action. Conversely their use can increase the risk of gastrointestinal bleeding, kidney injury, …

    View Full Text

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Copyright information:

    Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/