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Cross-sectional study
In depression, increased psychological reactance is associated with poorer treatment compliance
  1. Susanne Jaeger
  1. Department of Psychiatry and Psychotherapy I, Ulm University, Ravensburg, Germany
  1. Correspondence to : Dr Susanne Jaeger, Department of Psychiatry and Psychotherapy I, Ulm University, ZfP Suedwuerttemberg, Ravensburg 88214, Germany; susanne.jaeger{at}

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Implications for practice and research

  • Psychological reactance and doctor-attributed health locus of control are associated with medication adherence.

  • In particular, the correlation of reactance and non-adherence needs to be considered when giving clinical advice. This requires flexible and sensitive counselling skills from mental health professionals.

  • As these conclusions are based on correlations, further studies are needed to provide an insight into potential causal directions and to identify possible interventions.


Although it is a challenge to successful treatment of depression, medication non-adherence is a prevalent phenomenon. There is evidence that attitudes and beliefs are at least as important as side-effects in …

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  • Competing interests None.