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Systematic review with meta-analysis
Review: femoral nerve block may be the most effective option for pain relief following total knee replacement
  1. Aaron J Krych,
  2. Mark W Pagnano
  1. Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to : Dr Aaron J Krych, Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; krych.aaron{at}

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Implications for practice and research

  • Utilisation of continuous femoral nerve blockade (FNB) following knee replacement surgery can provide superior pain relief and fewer side effects, compared to traditional patient-controlled opioid analgesia.

  • Further research is needed to compare the effectiveness of FNB to other pain management strategies, such as local anaesthetic infiltration and multimodal oral pain medication.


Knee replacement surgery is a painful operation and patient satisfaction cannot be achieved without excellent postoperative analgesia. Traditional postoperative pain management, such as patient-controlled analgesia (PCA), can cause fluctuating pain levels with …

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  • Competing interests None.