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Implications for practice and research
Wong and colleagues’ study improves on current risk stratification models for sepsis.
The study's findings may lead to more homogeneous patient populations enrolled into clinical trials, increasing the chance of successful development of novel therapies for sepsis.
There are no immediate practice implications, due to clinically unavailable biomarker tests and a cumbersome algorithm.
Sepsis clinical trials have a history of failure, at least partially due to a tendency to enroll heterogeneous patient groups with mortality rates ranging from 20% to 50%.1 ,2 Current risk stratification models suffer from relatively modest predictive values.3
This was a prospective observational study designed to improve prognostic accuracy for prediction of 28-day mortality in patients with sepsis. An …
Competing interests None.