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Randomised controlled trial
Earlier thrombolytic treatment is associated with better outcomes following acute ischaemic stroke
  1. Naseeb Ullah,
  2. Michelle J Thompson,
  3. Adnan I Qureshi
  1. Zeenat Qureshi Stroke Institute and Department of Cerebrovascular Diseases, Centracare Health, St Cloud, MN, USA
  1. Correspondence to : Dr Adnan I Qureshi, 420 Delaware St, SE Minneapolis, MN 55455, USA; aiqureshi{at}

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Implications for practice and research

  • Optimisation is necessary in public education and hospital triage of the identification of factors such as arrival by ambulance and the importance of requesting emergency medical services (EMS) at scene of the stroke occurrence.1

  • The results of previous studies suggest that a disparity, observed between hospital-based outcomes for admissions that presented during regular hours and off hours, is not seen in all settings and so is a modifiable factor.2


The benefit of intravenous recombinant tissue plasminogen activator (rt-PA) in acute ischaemic stroke is time-dependent. Saver and colleagues analysed data from patients in hospitals …

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  • Competing interests None.