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Cohort study
Women admitted to hospital during pregnancy have increased risk of venous thromboembolism that persists up to 28 days postdischarge
  1. Saskia Middeldorp,
  2. Suzanne Mariëlla Bleker
  1. Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
  1. Correspondence to : Dr Saskia Middeldorp, Department of Internal Medicine, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands; s.middeldorp{at}

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Implications for practice and research

  • In pregnant women, the risk of venous thromboembolism (VTE) increases substantially during admission to hospital for reasons other than delivery, and persists up to 28 days postdischarge.

  • In pregnant women admitted to hospital, thrombosis prophylaxis should be considered and its benefits weighed against the risks. Studies into the optimal prophylactic approach are needed.


Pregnant women have a higher risk of VTE than non-pregnant women.1 VTE is the leading cause of maternal death in developed countries and many women develop post-thrombotic syndrome. In the general population, admission to hospital increases the risk of VTE by more than 100-fold. It …

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  • Competing interests None.