Article Text

Download PDFPDF
Cohort study
In adults with intellectual disability, discontinuation of antipsychotics is associated with reduction in weight, BMI, waist circumference and blood pressure
  1. Pierre Chue
  1. Department of Psychiatry, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
  1. Correspondence to : Professor Pierre Chue, Department of Psychiatry, Faculty of Medicine, University of Alberta, 9942-108 Street, Edmonton, Alberta, Canada T5K 2J5; pchue{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on: OpenUrlCrossRefPubMed

Implications for practice and research

  • Improvement in metabolic parameters can occur after discontinuation or dose reduction of antipsychotics.

  • Discontinuation of antipsychotics does not result in worsening of behaviours in the majority of patients.

  • Patients should be regularly reviewed with respect to the appropriateness of current antipsychotic regimens.


The prevalence of psychotropic drug use, particularly antipsychotics in patients with intellectual disability (ID), is high. The use of such agents for behavioural control frequently represents off-label use and is not supported by current guidelines.1 Certain psychiatric populations are very …

View Full Text


  • Competing interests None.