Article Text

Download PDFPDF
Cohort study
Children of mothers with iodine deficiency during pregnancy are more likely to have lower verbal IQ and reading scores at 8–9 years of age
  1. Angela M Leung,
  2. Gregory A Brent
  1. Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
  1. Correspondence to : Dr Angela M Leung, Division of Endocrinology 111D, Department of Medicine, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA; amleung{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on: OpenUrlCrossRefPubMedWeb of Science

Implications for practice and research

  • Children of mothers with iodine deficiency during the early pregnancy have an increased risk of impaired cognitive development at 8–9 years of age, even after adjustment for potential confounding factors.

  • Among iodine-deficient women, the child's cognitive scores showed a downward trend with a decreasing maternal iodine intake.

  • Further research is warranted to confirm the present findings.


Iodine deficiency is one of the leading causes of preventable brain damage. Although the relationship between maternal severe iodine deficiency and impaired cognitive function in children is well-established, less is …

View Full Text


  • Competing interests None.