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  • Late pregnancy use of selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors is associated with increased risk of postpartum haemorrhage

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Midwifery
Cohort study
Late pregnancy use of selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors is associated with increased risk of postpartum haemorrhage
  1. Cande V Ananth,
  2. Alexander M Friedman
  1. Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
  1. Correspondence to : Professor Cande V Ananth, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, 622 West 168th Street, New York, NY 10032, USA; cande.ananth{at}columbia.edu

https://doi.org/10.1136/eb-2013-101595

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    Commentary on: Palmsten K, Hernández-Díaz S, Huybrechts KF, et al. Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the USA. BMJ 2013;347:f4877.

    Implications for research and practice

    • Use of antidepressant medication is associated with increased risk for postpartum haemorrhage (PPH).

    • Further research is needed to establish a causal role between antidepressant medication use and PPH.

    • Clinicians should be aware of possible increased risk of postpartum haemorrhage when treating depression during pregnancy.

    Context

    Antidepressant medications are commonly used to manage psychiatric conditions in pregnancy. While extensive research related to teratogenesis and neonatal outcomes has been undertaken,1 there is relatively few data related to maternal obstetrical outcomes. Research from other specialties suggests that serotonin reuptake inhibitors (SSRIs) …

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    Footnotes

    • Competing interests None.