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Cohort study
Second trimester hyperemesis gravidarum is associated with increased risk of preterm pre-eclampsia, placental abruption and small for gestational age birth
  1. Angela Wood
  1. Carson-Newman University, Jefferson City, Tennessee, USA
  1. Correspondence to : Dr Angela Wood, Carson-Newman University, Nursing, 1646 Russell Avenue, Jefferson City, TN, 37760, USA; awood{at}

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Implications for practice and research

  • Patients experiencing late onset hyperemesis gravidarum (HG) and placental dysfunction disorders (PDD) should be closely monitored for disorders associated with abnormal placentation, including pre-eclampsia (PE), placental abruption and delayed intrauterine growth.

  • In addition, research is needed to study the potential effects of low-dose aspirin and increased blood pressure surveillance on the outcome of pregnancy in these patients.


While the incidence of HG is only 0.3–2%, the associated severe nausea and vomiting frequently lead to dehydration, malnutrition and hospitalisation.1 Aetiology of HG is unclear, although most researchers consider the hormonal changes to be at least partly responsible. This study has an interesting hypothesis: that …

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  • Competing interests None.