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Implications for practice and research
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Professional societies (American Society of Anesthesiology (ASA) and the European Society of Anaesthesiology (ESA)) recommend maximising non-opioid over opioid analgesics and utilising a multimodal approach to perioperative pain management.
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This systematic review (SR) examines the effects of combining codeine and ibuprofen.
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The authors of SR conclude that ibuprofen and codeine combinations may provide enhanced efficacy.
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Future research should focus on whether combination agents provide better analgesia than their individual constituent alone.
Context
Postoperative pain control remains challenging. Historically, there has been a reliance on opioids for pain management. The American Society of Anesthesiology's (ASA's) most recent guidelines recommend maximising non-opioid agents with around-the-clock dosing and using opioids supplementally.1 Derry and colleagues performed a meticulous SR examining the analgesic efficacy of single-dose ibuprofen and codeine …