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Implications for practice and research
Female adolescents with a shorter duration between the age of menarche and first sexual intercourse are at an increased risk of high-grade cervical disease.
Clinical counselling should include clear recommendations to obtain human papillomavirus (HPV) vaccination well before first intercourse to reduce the future risk of high-grade cervical lesions among sexually naïve female adolescents.
Ruiz and colleagues present associations between a shorter interval between menarche and first sexual intercourse on subsequent risk of high-grade cervical intraepithelial neoplasia (CIN-2+) or adenocarcinoma in situ among young women (16–23 years), in phase III randomised controlled trials (RCTs) in Colombia …
Competing interests JSS has received unrestricted grants and consultancies from GSK or Merck Corporation over the past 5 years.