Article Text

Download PDFPDF
Systematic review
Cochrane reviews allow firm conclusions to be made about the effectiveness of various local and systemic treatments for wounds and ulcers
  1. Katherine R Jones
  1. School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA
  1. Correspondence to : Dr Katherine R Jones
    School of Nursing, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4909, USA; katherine.jones{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on: OpenUrlCrossRefPubMed

Implications for practice and research

  • Evidence-supported interventions to manage chronic wounds include elastic, high or multilayer compression and systemic pentoxifyllene for venous ulcers; hyperbaric oxygen and local hydrogels applied after debridement for diabetic ulcers; systemic prostanoids and spinal cord stimulation for arterial ulcers; and avoidance of local therapeutic ultrasound for healing pressure ulcers.

  • Evidence-supported interventions to prevent pressure ulcers include high-specification foam and low air-loss mattresses, and pressure-relieving overlays on operating room tables.

  • Evidence-supported interventions for acute wound healing include topical honey for burns, tap water for cleansing soft tissue injury, prophylactic antibiotics for hand bites and avoidance of silver sulfadiazine as a topical agent.

  • Many common wound care therapies have had no trials conducted to assess their effectiveness. More high-quality research …

View Full Text


  • Competing interests None.