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Implications for practice and research
Second trimester exposure to antidepressants was associated with preterm birth.
Third trimester exposure was associated with infant convulsions.
The absolute risk for both outcomes is extremely low and most infants will not have these complications.
Decisions about whether to use antidepressants during pregnancy should include the severity of the mother's psychiatric illness.
Large studies that include severity of the mother's illness need to be conducted.
Approximately 10–20% of women will meet the criteria for major depressive disorder (MDD) during their lifetime, including during pregnancy.1 Rates of antidepressant exposure …
Competing interests JLP has received expert testimony fees from Astra Zeneca and Pfizer, and has served on an Advisory Board for Pfizer.