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Commentary on: De Berardis G, Lucisano G, D'Ettorre A, et al. Association of aspirin use with major bleeding in patients with and without diabetes. JAMA 2012;307:2286–94.
Implications for practice and research
Low-dose aspirin (≤300 mg/day) increases the risk of major bleeding.
Individuals with diabetes have a higher risk of bleeding independent of aspirin exposure.
Future work should include comparative effectiveness studies to help inform treatment strategies based on individual risks, benefits, patient preferences and values.
Aspirin has a proven role in the secondary prevention of cardiovascular disease.1 Further interest has emerged on extending its use for primary prevention. However, the desired benefits of aspirin need to be carefully balanced against the potential harms.1 Although the cardioprotective benefit of aspirin has been well defined, the general risk of haemorrhage remains uncertain as existing data are mostly limited to …
Competing interests None.