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Randomised controlled trial
Vitamin E increases prostate cancer risk in middle-aged men relative to placebo: no significant association observed with selenium, either alone or in combination with vitamin E
  1. Gwen Wyatt
  1. College of Nursing, Michigan State University, East Lansing, Michigan, USA
  1. Correspondence to Gwen Wyatt
    College of Nursing, Michigan State University, 515 W Fee Hall, East Lansing, MI 48824, USA; gwen.wyatt{at}

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Commentary on: OpenUrlCrossRefPubMedWeb of Science

Implications for practice and research

  • Clinicians should inform patients that vitamin E significantly increased the risk of prostate cancer among healthy men, and should be avoided.

  • Extended follow-up of common doses of vitamins and supplements may reveal new and critically significant findings.


The lifetime risk for prostate cancer in the USA is currently estimated to be 16%. The objective of this study was to determine the long-term effect of vitamin E and selenium on the risk of prostate cancer in healthy men who had participated in the …

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  • Competing interests None.