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Case control study
Use of non-aspirin NSAIDs during pregnancy may increase the risk of spontaneous abortion
  1. Pamela Verma1,
  2. Christine A Clark2,
  3. Karen A Spitzer2,
  4. Carl A Laskin2,
  5. Joel Ray1,
  6. Gideon Koren3
  1. 1Department of Medicine St. Michael's Hospital, Ontario, Canada
  2. 2Mount Sinai Hospital and LifeQuest Centre for Reproductive Medicine, Ontario, Canada
  3. 3Division of Clinical Pharmacology/Toxicology, Hospital for Sick Children, Toronto, Canada
  1. Correspondence to Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology/Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; gideon.koren{at}

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Commentary on: OpenUrlAbstract/FREE Full Text

Implications for practice and research

  • Data from this study support the assertion that the use of non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy is associated with increased risk of spontaneous abortion and should, therefore, be used with caution.

  • However, other factors such as socio-economic status and co-existing illnesses may have biased these results.

  • Further research is needed to explore the effect of taking NSAIDs during pregnancy and the other factors identified.

  • Future research should include data relating to the use of both prescription and over-the-counter NSAIDs.


NSAIDs are one of the commonest classes of drugs taken by pregnant …

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  • Competing interests None.