Article Text

Download PDFPDF
Systematic review
Are antiemetics still contraindicated for gastroenteritis in children? Solid evidence now supports the safe use of ondansetron
  1. James E Colletti
  1. Department of Emergency Medicine, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to James E Colletti
    Department of Emergency Medicine, Mayo Clinic, 200 First St, NW Rochester, MN 55902, USA; colletti.james{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on:

Implications for practice and research

  • In children presenting with vomiting from acute gastroenteritis, ondansetron is a reasonable therapy to allow for successful oral rehydration.

  • Further research on ondansetron and rehydration should investigate the effects of different dosing regimens, time to cessation of vomiting after antiemetic administration, as well as a cost-effectiveness analysis.


Acute gastroenteritis (AGE) is a common reason for a child to require emergency care and hospitalisation. In children under the age of 5 years, dehydration secondary to AGE is responsible for as many as 200 000 hospitalisations in the USA and 24 000 in the UK each year.1 ,2 …

View Full Text


  • Competing interests None.