Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Objectives and overview
The objective of this study was to determine which class of non-opioid analgesics – paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs) or cyclooxygenase-2 (COX-2) inhibitors – was the most effective at reducing intravenous. Morphine consumption and opioid related adverse events following major surgery.
The authors conducted a systematic review which combined a review by Elia and colleagues1 with the results of 20 new studies. All studies were randomised controlled trials (RCTs) that reported postoperative 24 h cumulative morphine consumption. The other outcomes of interest were morphine-related adverse events and postoperative bleeding. With the aid of a biostatistician, the authors report a series of mixed treatment comparisons.
Results and major conclusions
The major finding of this article was that compared to placebo (45.26 mg) NSAIDs or COX-2 inhibitors reduced by 10.9 mg, and paracetamol reduced by 6.3 mg, 24 h postoperative …
Competing interests None.