Chronic fatigue syndrome (CFS) is a debilitating condition for which there are few proven treatments that are not delivered by specialist therapists. Wearden and colleagues tested an intervention designed to test whether non-specialists can effectively manage CFS in primary care. The nurse-delivered intervention, known as pragmatic rehabilitation, involves the collaborative development of an activity programme between patient and the therapist. A randomised clinical trial format was used and 297 patients were randomly allocated to one of three treatments: (1) pragmatic rehabilitation, (2) supportive listening and (3) treatment …