This paper addresses two key components of nurse education: the acquisition of clinical skills, and the use of computer-assisted learning (CAL). Also emphasised is the importance of clinical-skills acquisition in nursing, with particular reference to handwashing. It states how high levels of competency in hand washing are essential to ensure patient safety and prevent hospital acquired infections. The second important element addressed is the potential use of CAL in the teaching of clinical skills in nursing with particular reference to both the theory and skills of handwashing. Additionally, the paper refers to the lack of empirical evidence regarding the effectiveness of CAL in the teaching and learning of nursing skills. What is reported in the paper adds to the limited body of knowledge in this area.