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Systematic review
Intensive glucose control in type 2 diabetes reduces cardiovascular disease, but not cardiovascular or all-cause mortality, and increases risk of severe hypoglycaemia
  1. Deborah Chyun
  1. Deborah Chyun
    Florence S. Downs Director, Program in Nursing Research and Theory Development, College of Nursing, New York University, 726 Broadway, New York, NY 10003, USA; dc116{at}

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Previous studies—the Diabetes Control and Complications Trial1 in type 1 diabetes and the United Kingdom Prospective Diabetes Study2 in type 2 diabetes—have clearly demonstrated the benefits of intensive glucose control for the prevention of the microvascular complications of diabetes (neuropathy, nephropathy and retinopathy). In addition, long-term follow-up of the younger subjects with type 1 diabetes who were enrolled in the Diabetes Control and Complications Trial demonstrated that those in the intensive arm had a reduced risk of developing cardiovascular disease (CVD), long after the initial phase of the study.3 However, the effects …

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  • Competing interests None.