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Intravascular catheter dressings with chlorhexidine-impregnated sponges reduced infections in the ICU

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Do intravascular catheter dressings with chlorhexidine gluconate–impregnated sponges (CHGISs) reduce catheter-related infections (CRIs) compared with standard dressings in intensive care unit (ICU) patients? Are dressing changes every 7 days non-inferior to changes every 3 days?



2 × 2 factorial randomised controlled trial. NCT00417235.




blinded (microbiologists, outcome assessors, {data analysts, and safety committee}*).

Follow-up period:

48 hours after ICU discharge.


7 ICUs in 3 university and 2 general hospitals in France.


1653 patients >18 years of age (median age 62 y, 64% men, based on 1636 patients) requiring catheters for ⩾48 hours. Exclusion criteria were allergy to chlorhexidine or transparent dressings.


CHGIS dressings, 3-day change (n = 412); CHGIS dressings, 7-day change (n = 413); standard dressings, 3-day change (n = 416); or standard dressings, 7-day change (n = 412). In …

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  • Sources of funding French Ministry of Health; Biopatch dressings donated by Ethicon Inc.