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Intravascular catheter dressings with chlorhexidine-impregnated sponges reduced infections in the ICU

https://doi.org/10.1136/ebn.12.4.115

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    Questions

    Do intravascular catheter dressings with chlorhexidine gluconate–impregnated sponges (CHGISs) reduce catheter-related infections (CRIs) compared with standard dressings in intensive care unit (ICU) patients? Are dressing changes every 7 days non-inferior to changes every 3 days?

    Methods

    Design:

    2 × 2 factorial randomised controlled trial. Clinicaltrials.gov NCT00417235.

    Allocation:

    {concealed}.*

    Blinding:

    blinded (microbiologists, outcome assessors, {data analysts, and safety committee}*).

    Follow-up period:

    48 hours after ICU discharge.

    Setting:

    7 ICUs in 3 university and 2 general hospitals in France.

    Patients:

    1653 patients >18 years of age (median age 62 y, 64% men, based on 1636 patients) requiring catheters for ⩾48 hours. Exclusion criteria were allergy to chlorhexidine or transparent dressings.

    Interventions:

    CHGIS dressings, 3-day change (n = 412); CHGIS dressings, 7-day change (n = 413); standard dressings, 3-day change (n = 416); or standard dressings, 7-day change (n = 412). In …

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    Footnotes

    • Sources of funding French Ministry of Health; Biopatch dressings donated by Ethicon Inc.