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Question
Does a very low calorie diet (VLCD) plus intensive lifestyle counselling improve mild obstructive sleep apnoea (OSA) in overweight patients?
Methods
Design:
randomised controlled trial (RCT).
Allocation:
unclear allocation concealment.
Blinding:
blinded (outcome assessors).
Follow-up period:
1 year.
Setting:
Kuopio University Hospital, Kuopio, Finland.
Patients:
81 patients 18–65 years of age (mean age 51 y, 65% men) who had a body mass index of 28–40 kg/m2 and an apnoea-hypopnoea index (AHI) of 5–15 events/hour. Exclusion criteria were active treatment for OSA, pregnancy, and chronic kidney, thyroid, or liver disease.
Intervention:
a VLCD (600–800 kcal/d) for 12 weeks plus intensive lifestyle counselling for 1 year (n = 40) or general oral and written …
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