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Does a very low calorie diet (VLCD) plus intensive lifestyle counselling improve mild obstructive sleep apnoea (OSA) in overweight patients?
randomised controlled trial (RCT).
unclear allocation concealment.
blinded (outcome assessors).
Kuopio University Hospital, Kuopio, Finland.
81 patients 18–65 years of age (mean age 51 y, 65% men) who had a body mass index of 28–40 kg/m2 and an apnoea-hypopnoea index (AHI) of 5–15 events/hour. Exclusion criteria were active treatment for OSA, pregnancy, and chronic kidney, thyroid, or liver disease.
a VLCD (600–800 kcal/d) for 12 weeks plus intensive lifestyle counselling for 1 year (n = 40) or general oral and written …
Sources of funding Juho Vainio Foundation; Yrjö Jahnsson Foundation; Jalmari and Rauha Ahokkaan Foundation; Finnish Anti-Tuberculosis Foundation.