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Do central venous catheters treated with anti-infective agents (AI-CVCs) prevent catheter-related bloodstream infections (CRBSIs)?
Included studies compared AI-CVCs with standard CVCs or a different AI-CVC for preventing CRBSIs in patients requiring a CVC. Primary outcome was diagnosis of a CRBSI (the same micro-organism identified in both the catheter and the bloodstream).
Medline, EMBASE/Excerpta Medica, SCI/Web of Science, SCI/ISI Proceedings, and Cochrane Library (to Sep 2007) were searched for randomised controlled trials (RCTs). Trials involving AI-CVCs that required in-house preparation were excluded. 38 RCTs (n = ∼9000 patients) met the selection criteria. Methodological quality of the trials was generally poor: 10 RCTs reported …
Source of funding: Health Technology Assessment Programme.