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Review: tight glucose control increases risk of hypoglycaemia but not short-term mortality in critically ill adults

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R Wiener

Dr R Wiener, Department of Veterans Affairs Medical Center, White River Junction, VT, USA;


What are the benefits and risks of tight glucose control in critically ill adults?


Included studies compared tight glucose control (glucose goal <150 mg/dl [8.3 mmol/l] using an insulin infusion) with usual care in patients in adult intensive care units (ICUs) and had one of the outcomes of interest as a primary or secondary end point. Studies of primarily intraoperative interventions or that could not provide adequate outcome or methodological data were excluded. Outcomes of interest were hospital or 30-day mortality, septicaemia (sepsis, septicaemia, bacteraemia, or positive blood cultures), need for dialysis in patients without a pre-existing need, and …

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  • Source of funding: Dartmouth Medical School; Dartmouth-Hitchcock Medical Center; US Department of Veterans Affairs.