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Vitamin E or vitamin C supplements did not differ from placebo for major cardiovascular events and mortality

https://doi.org/10.1136/ebn.12.2.48

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    H D Sesso

    Dr H D Sesso, Brigham and Women’s Hospital, Boston, MA, USA; hsesso@hsph.harvard.edu

    QUESTION

    In men at lower risk of cardiovascular disease (CVD), do vitamin E and vitamin C supplements reduce major CVD events?

    METHODS

    Design:

    randomised placebo controlled trial (Physicians’ Health Study II). ClinicalTrials.gov NCT00270647.

    Allocation:

    unclear allocation concealment.

    Blinding:

    blinded (patients, clinicians, and outcome assessors)

    Follow-up period:

    ⩽10 years (mean 8 y).

    Setting:

    USA.

    Patients:

    14 641 male physicians ⩾50 years of age (mean age 64 y). Men with a history of myocardial infarction (MI), stroke, or cancer were included. Exclusion criteria were history of cirrhosis, active liver disease, anticoagulant use, or serious illness. 5.1% of men had prevalent CVD.

    Intervention:

    after stratification for age, previous cancer or …

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    Footnotes

    • Source of funding: National Institutes of Health and BASF Corporation.