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Review: weight-reducing agents improve glycaemic control and reduce progression to diabetes

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S Czernichow

Dr S Czernichow, Unite de Recherche en Nutrition Humaine, Bobigny, France;


How do weight-reducing agents affect glycaemic parameters and risk of type 2 diabetes in predisposed individuals?


Included studies were randomised, double-blind, placebo controlled trials (RCTs) that evaluated the effects of weight-reducing agents (eg, orlistat, sibutramine, and rimonabant) on fasting glucose or glycated haemoglobin (HbA1c) concentrations and had a duration of ⩾1 year. Studies of mixed populations were excluded. Outcomes included weight loss, fasting glucose and HbA1c concentrations, and diabetes.


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