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A nurse-delivered intervention was effective for depression in patients with cancer

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M Sharpe

Professor M Sharpe, University of Edinburgh, Edinburgh, UK;


What is the effectiveness of a complex, nurse-delivered intervention for treating major depression in patients with cancer?



randomised controlled trial (RCT) (Symptom Management Research Trials [SMaRT]).




blinded {data collectors, outcome assessors, data analysts, and safety committee}.*

Follow-up period:

12 months.


a regional cancer centre in the UK.


200 outpatients (mean age 57 y, 71% women) who had cancer with prognosis ⩾6 months and major depressive disorder (Symptom Checklist [SCL]-20 score ⩾1.75) for ⩾1 month. Exclusion criteria included epilepsy, concurrent intensive anticancer treatment (eg, frequent chemotherapy or radiotherapy), and receipt of specialist psychiatric care.


a nurse-delivered intervention plus usual care (n = 101) or usual care alone (n = 99). The intervention consisted …

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  • Source of funding: Cancer Research UK.