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Review: varenicline, bupropion, and nicotine replacement therapies are effective for smoking cessation at 6 or 12 months

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M J Eisenberg

Dr M J Eisenberg, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada;


How do various pharmacotherapies compare for smoking cessation?


Studies selected compared any pharmacotherapy with placebo and reported biochemically validated measures of smoking abstinence. Trials that were unblinded or that evaluated reduced cigarette use, spontaneous cessation among smokers unwilling to quit, or smokers with chronic disease were excluded. Outcome was smoking cessation.


Medline, EMBASE/Excerpta Medica, Cochrane Library, and US Centers for Disease Control and Prevention’s Tobacco Information and Prevention database were searched for randomised controlled trials (RCTs). 69 RCTs (n = 32 908) …

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  • Source of funding: Canadian Institutes of Health Research.