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Causation
Enalapril and captopril increased mortality compared with ramipril in elderly patients with heart failure

http://dx.doi.org/10.1136/ebn.11.4.123

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    L Pilote

    Dr L Pilote, McGill University Health Centre, Montreal, Quebec, Canada; louise.pilote@mcgill.ca

    QUESTION

    Does type of angiotensin-converting enzyme (ACE) inhibitor prescribed affect mortality in elderly patients with heart failure?

    METHODS

    Design:

    retrospective cohort study using government administrative databases, with mean follow-up of 2.1 years.

    Setting:

    Ontario, Quebec, and British Columbia, Canada.

    Patients:

    43 316 patients 65–105 years of age (median age 78 y, 52% women) who were discharged from hospital over a 4.25–year period with a primary diagnosis of heart failure, had not been admitted to hospital for this indication in the previous 3 years, and filled a prescription for an ACE inhibitor within 30 days of discharge.

    Risk factor:

    type …

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    Footnotes

    • Source of funding: Canadian Institutes of Health Research.