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  • Chorioamnionitis, gestational age, male sex, birth weight, and illness severity predicted positive autism screening scores in very-low-birth-weight preterm infantsCommentary

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Chorioamnionitis, gestational age, male sex, birth weight, and illness severity predicted positive autism screening scores in very-low-birth-weight preterm infants

https://doi.org/10.1136/ebn.11.4.122

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    C Limperopoulos

    Dr C Limperopoulos, Montreal Children’s Hospital, Montreal, Quebec, Canada; catherine.limperopoulos@childrens.harvard.edu

    QUESTION

    What are the prevalence and risk factors of early autistic features in young children who had very low birth weights?

    METHODS

    Design:

    inception cohort of preterm infants followed up to 18–24 months of age adjusted for prematurity.

    Setting:

    {a hospital in Boston, Massachusetts, USA}.*

    Patients:

    consecutive series of 103 preterm infants with birth weights <1500 g (median gestational age 26 wks, 60% boys, median birth weight 890 g). Exclusion criteria were known or suspected cerebral dysgenesis, dysmorphic syndromes, or chromosomal disorders. 8 infants died, and 4 were lost to follow-up.

    Prognostic factors:

    maternal age and temperature, acute intrapartum or antepartum haemorrhage, preterm labour, placental infection, gestational age at birth, birth weight, sex, admission Score of …

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    Footnotes

    • Source of funding: LifeBridge Fund; Caroline Levine Foundation; Trust Family Foundation; Canada Research Chairs Program.