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Negative pressure wound therapy promoted healing of diabetic foot ulcers more than advanced moist wound therapy

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P A Blume

Dr P A Blume, North American Center for Limb Preservation, New Haven, CT, USA;


Is negative pressure wound therapy (NPWT) using vacuum-assisted closure more effective than advanced moist wound therapy (AMWT) for diabetic foot ulcers?



randomised controlled trial.





Follow-up period:

16 weeks (efficacy) and 26 weeks (safety).


29 diabetic foot and wound clinics in the USA and Canada. Treatment occurred mainly at home (92% of treatment days).


341 patients ⩾18 years of age (mean age 58 y, 79% men) with adequately controlled diabetes who had a stage 2 or 3 calcaneal, dorsal, or plantar foot ulcer ⩾2 cm2 in area after debridement and adequate lower extremity perfusion. Exclusion criteria included active Charcot disease, collagen vascular disease, ulcer …

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  • Source of funding: KCI USA Inc.