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Review: venepuncture is less painful than heel lance for blood sampling in neonates

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V Shah

Dr V Shah, Mount Sinai Hospital, Toronto, Ontario, Canada;


Is venepuncture less painful than heel lance for blood sampling in healthy neonates?


Studies selected compared venepuncture and heel lance for blood sampling in healthy term neonates. Outcomes were neonatal pain response (assessed by a validated measure), maternal anxiety, sampling time, and need for repeat skin puncture.


Medline, CINAHL, and EMBASE/Excerpta Medica (to Jun 2007); Cochrane Central Register of Controlled Trials (Issue 2, 2007); and reference lists were searched for randomised controlled trials (RCTs) or quasi-randomised trials. 5 RCTs (n = 317, 47–59% boys) met the selection criteria. All trials had adequate allocation concealment; in no trial were investigators or participants blinded, but the outcome …

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  • Source of funding: no external funding.