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Both low-dose and micro-dose 17β-oestradiol are effective for postmenopausal hot flushes

https://doi.org/10.1136/ebn.11.2.53

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    G A Bachmann

    Dr G A Bachmann, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA; gloria.bachmann@umdnj.edu

    QUESTION

    Does micro-dose 17β-oestradiol reduce the frequency and severity of hot flushes in symptomatic postmenopausal women?

    METHODS

    Design:

    randomised, placebo-controlled trial.

    Allocation:

    concealed.

    Blinding:

    blinded (patients, clinicians, and data collectors).

    Follow-up period:

    12 weeks.

    Setting:

    48 centres in the US.

    Patients:

    425 healthy postmenopausal women ⩾40 years of age (mean age 53 y) who had an average of ⩾7 moderate or severe hot flushes per day for ⩾1 week during screening. Women taking hormone therapy or other drugs that might affect vasomotor symptoms underwent a wash-out period. Exclusion criteria included abnormal Pap test result, abnormal vaginal bleeding, and history of thrombophlebitis or thromboembolic disorder.

    Intervention:

    transdermal …

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    Footnotes

    • Source of funding: Schering AG, Berlin, Germany.