You are here

Article Text

Article menu
Download PDFPDF
Treatment
Both low-dose and micro-dose 17β-oestradiol are effective for postmenopausal hot flushes

http://dx.doi.org/10.1136/ebn.11.2.53

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    G A Bachmann

    Dr G A Bachmann, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA; gloria.bachmann@umdnj.edu

    QUESTION

    Does micro-dose 17β-oestradiol reduce the frequency and severity of hot flushes in symptomatic postmenopausal women?

    METHODS

    Design:

    randomised, placebo-controlled trial.

    Allocation:

    concealed.

    Blinding:

    blinded (patients, clinicians, and data collectors).

    Follow-up period:

    12 weeks.

    Setting:

    48 centres in the US.

    Patients:

    425 healthy postmenopausal women ⩾40 years of age (mean age 53 y) who had an average of ⩾7 moderate or severe hot flushes per day for ⩾1 week during screening. Women taking hormone therapy or other drugs that might affect vasomotor symptoms underwent a wash-out period. Exclusion criteria included abnormal Pap test result, abnormal vaginal bleeding, and history of thrombophlebitis or thromboembolic disorder.

    Intervention:

    transdermal …

    View Full Text

    Footnotes

    • Source of funding: Schering AG, Berlin, Germany.